Vitamin D supplementation and lower respiratory tract infection in infants: a nested case-control study.

ABSTRACT:

Purpose

To assess the association between vitamin D (VD) supplementation and the risk of lower respiratory tract infection (LRTI) among infants.

Methods

This is a nested case-control study from an ongoing prospective birth cohort in Wuhan from 2013. Cases were subjects free of neonatal pneumonia but later developed LRTI during infancy, who were matched with five randomly selected controls by infant sex, birth year, and birth season. We included 190 cases and 950 controls in the final analysis. The primary outcome was the first LRTI incident and the exposure was VD supplementation from birth to the index endpoint. The association between VD supplementation and LRTI risk was assessed using the Cox proportional-hazards regression model.

Results

Infants taking supplements

SUBMITTER: Hong M 

PROVIDER: S-EPMC9127486 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature