Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms.

ABSTRACT:

Importance

Neurologic symptoms are common in COVID-19, but the central nervous system (CNS) pathogenesis is unclear, and viral RNA is rarely detected in cerebrospinal fluid (CSF).

Objective

To measure viral antigen and inflammatory biomarkers in CSF in relation to neurologic symptoms and disease severity.

Design, setting, and participants

This cross-sectional study was performed from March 1, 2020, to June 30, 2021, in patients 18 years or older who were admitted to Sahlgrenska University Hospital, Gothenburg, Sweden, with COVID-19. All patients had CSF samples taken because of neurologic symptoms or within a study protocol. Healthy volunteer and prepandemic control groups were included.

Exposure

SARS-CoV-2 infection.

Main outcomes and measures

Outcomes

SUBMITTER: Eden A 

PROVIDER: S-EPMC9127556 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature