Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome.

ABSTRACT:

Importance

People with Down syndrome have a high risk of developing Alzheimer disease dementia. However, penetrance and age at onset are considered variable, and the association of this disease with life expectancy remains unclear because of underreporting in death certificates.

Objective

To assess whether the variability in symptom onset of Alzheimer disease in Down syndrome is similar to autosomal dominant Alzheimer disease and to assess its association with mortality.

Design, setting, and participants

This study combines a meta-analysis with the assessment of mortality data from US death certificates (n = 77 347 case records with a International Classification of Diseases code for Down syndrome between 1968 to 2019; 37 900 [49%] female) and from a longitudinal coho

SUBMITTER: Iulita MF 

PROVIDER: S-EPMC9127560 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature