Underground railway particulate matter and susceptibility to pneumococcal infection.

ABSTRACT:

Background

Concentrations of particulate matter less than 10 microns (PM₁₀) on underground railways are higher than those near urban roads. Traffic-related PM₁₀ increases pneumococcal infection via increasing the expression of platelet-activating factor receptor (PAFR), a receptor co-opted by pneumococci to adhere to cells. To date, it is unknown whether underground railway PM₁₀ increases pneumococcal infection. This study sought to determine the effect of London Underground (LU) PM₁₀ on; i) pneumococcal adhesion to airway cells, and ii) susceptibility to pneumococcal disease.

Methods

A549 cells and human primary airway epithelial cells were cultured with 20 µg/mL PM₁₀ from the Bakerloo (B-PM₁₀) and Jubilee (J

SUBMITTER: Miyashita L 

PROVIDER: S-EPMC9127572 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature