Contrasting behavior between the three human monocyte subsets in dengue pathophysiology.

ABSTRACT: Monocytes are known to play a critical role in dengue pathophysiology. However, which monocyte subset expresses what inflammatory mediator(s) and what transcriptional features distinguish each of the monocyte subset in vivo remain poorly understood. In this study we provide a detailed transcriptional analysis of the three human monocyte subsets in healthy children and in children with dengue febrile illness. Notably, we found that the CD14⁺ CD16high intermediate monocyte subset from dengue patients highly upregulated key genes involved in mediating inflammation, endothelial dysfunction, vascular permeability, tissue extravasation, and clot prevention compared to healthy children. The CD14⁺CD16low classical monocytes shared some of these features. These two subs

SUBMITTER: Maheshwari D 

PROVIDER: S-EPMC9127603 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature