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Diversified Polyketides With Anti-inflammatory Activities From Mangrove Endophytic Fungus Daldinia eschscholtzii KBJYZ-1.

ABSTRACT: In total, five new polyketide derivatives: eschscholin B (2), dalditone A and B (3 and 4), (1R, 4R)-5-methoxy-1,2,3,4-tetrahydronaphthalene-1,4-dio (5), and daldilene A (6), together with 10 known as analogs (1, 7-15) were isolated from the mangrove endophytic fungus Daldinia eschscholtzii KBJYZ-1. Their structures and absolute configurations were established by extensive analysis of NMR and HRESIMS spectra data combined with ECD calculations and the reported literature. Compounds 2 and 6 showed significant cell-based anti-inflammatory activities with IC50 values of 19.3 and 12.9 μM, respectively. In addition, western blot results suggested that compound 2 effectively inhibits the expression of iNOS and COX-2 in LPS-induced RAW264.7 cells. Further molecular biology work revealed the potential mechanism of 2 exerts anti-inflammatory function by inactivating the MAPK and NF-κB signaling pathways.

SUBMITTER: Wang G 

PROVIDER: S-EPMC9127611 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Diversified Polyketides With Anti-inflammatory Activities From Mangrove Endophytic Fungus <i>Daldinia eschscholtzii</i> KBJYZ-1.

Wang Guisheng G   Yin Zhenhua Z   Wang Senye S   Yuan Yilin Y   Chen Yan Y   Kang Wenyi W  

Frontiers in microbiology 20220510

In total, five new polyketide derivatives: eschscholin B (<b>2</b>), dalditone A and B (<b>3</b> and <b>4</b>), (1<i>R</i>, 4<i>R</i>)-5-methoxy-1,2,3,4-tetrahydronaphthalene-1,4-dio (<b>5</b>), and daldilene A (<b>6</b>), together with 10 known as analogs (<b>1</b>, <b>7</b>-<b>15</b>) were isolated from the mangrove endophytic fungus <i>Daldinia eschscholtzii</i> KBJYZ-1. Their structures and absolute configurations were established by extensive analysis of NMR and HRESIMS spectra data combine  ...[more]

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