Highly enantioselective copper-catalyzed propargylic amination to access N-tethered 1,6-enynes.

ABSTRACT: A highly enantioselective copper-catalyzed propargylic amination starting from benzylic allylic amines has been developed with a new chiral N,N,P ligand. A series of N-tethered 1,6-enynes were synthesized in good to excellent yields with excellent enantioselectivities. Utilization of transition metal-catalyzed cycloisomerization of 1,6-enynes provides several enantioselectively enriched chiral five-membered N-heterocycles efficiently.

SUBMITTER: Li SJ 

PROVIDER: S-EPMC9127637 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature