Multistage antiplasmodial activity of hydroxyethylamine compounds, in vitro and in vivo evaluations.

ABSTRACT: Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of Plasmodium species. New therapeutics acting against the pathogenic asexual and sexual stages, including liver-stage malarial infection, have now attained more attention in achieving malaria eradication efforts. In this paper, two previously identified potent antiplasmodial hydroxyethylamine (HEA) compounds were investigated for their activity against the malaria parasite's multiple life stages. The compounds exhibited notable activity against the artemisinin-resistant strain of P. falciparum blood-stage culture with 50% inhibitory concentrations (IC₅₀) in the low micromolar range. The compounds' cytotoxicity on HEK293, HepG2 and Huh-7 cells

SUBMITTER: Sharma N 

PROVIDER: S-EPMC9127639 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature