Monosubstituted Coumarins Inhibit Epinephrine-induced Platelet Aggregation.

ABSTRACT:

Aim

The aim of this study was to evaluate the in vitro effect of coumarin and 15 monosubstituted derivatives on the inhibition of human platelet aggregation induced by various proaggregatory agonists, particularly by epinephrine.

Background

The emergence of residual platelet reactivity during the use of conventional antiplatelet agents (acetylsalicylic acid and clopidogrel) is one of the main causes of double therapy´s therapeutic failure. Platelet adrenoceptors participate in residual platelet reactivity. Therefore, it is necessary to develop new antiplatelet agents that inhibit epinephrine-induced platelet aggregation as a new therapeutic strategy. Information on the antiplatelet activity of coumarins in inhibiting epinephrine-induced aggregation is limited.

Objective</

SUBMITTER: Jimenez-Orozco FA 

PROVIDER: S-EPMC9127734 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature