Elevated C-reactive protein among symptomatic youth with bipolar disorder.

ABSTRACT:

Rationale and objectives

Increased levels of high-sensitivity C-reactive protein (CRP) are associated with mood symptoms in adults with bipolar disorder (BD). The few studies on this topic in youth with BD have not included controls. We, therefore, examined CRP levels in relation to symptomatic status in youth with and without BD.

Methods

Participants included 154 youth (mean age 17 years; 48 asymptomatic BD, 39 symptomatic BD, 67 healthy controls (HC)). Rank analysis of covariance test examined group differences in CRP, controlling for age and sex. Correlation between CRP and mood symptom severity was examined using Spearman's correlation within the BD group.

Results

There were significant group differences in CRP levels (F_(2,151) = 5.06, p =

SUBMITTER: Zou Y 

PROVIDER: S-EPMC9127784 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature