Nonalcoholic fatty liver disease and health outcomes: An umbrella review of systematic reviews and meta-analyses.

ABSTRACT:

Purpose

A large number of systemic reviews and meta-analyses have explored the relationship between nonalcoholic fatty liver disease (NAFLD) and multiple health outcomes. The aim of this study is to conduct an umbrella review to assess the strength and evidence for the association between NAFLD and health outcomes.

Methods

We systematically identified the present meta-analyses of observational studies reporting an association between NAFLD and health outcomes. For each meta-analysis, we assessed the quality with AMSTAR2 and graded the epidemiologic evidence.

Results

Fifty-four articles comprising 111 unique meta-analyses were included in this study. Eighty-five unique outcomes showed significant associations (P ← 0.05), whereas 26 unique outcomes showed insigni

SUBMITTER: Zhong L 

PROVIDER: S-EPMC9127863 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature