Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.

ABSTRACT:

Objectives

To study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters.

Methods

This study was carried out on 118 diabetic patients and 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay was used for rs8050136 genotyping.

Results

The frequency of the genotype AA was the same among T2DM and healthy control groups (21%). However, the frequency of genotype CC was 19.5% in T2DM patients and 24.5% in control individuals. There was no significant association between FTO SNP rs8050136 and an increased risk of T

SUBMITTER: Yousuf AM 

PROVIDER: S-EPMC9127913 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature