Unknown

Dataset Information

0

Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern.

ABSTRACT: The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Here, we found that the VOC diverge at the nucleocapsid protein used by four commercial Ag-RDTs for the viral detection. Relative to the original D614G variant, there was a 10-fold loss of detection for the Delta and Alpha variants in certain Ag-RDTs, a reduction above the threshold required to isolate the viable virus. However, Beta and Omicron variants did not lose the detection capacity. As the new VOC arise, successful contact tracing requires continuous monitoring of Ag-RDTs performance.

SUBMITTER: Raich-Regue D 

PROVIDER: S-EPMC9127986 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Here, we found that the VOC diverge at the nucleocapsid protein used by four commercial Ag-RDTs for the viral detection. Relative to the original D614G variant, there was a 10-fold loss of detection for  ...[more]

Similar Datasets

Unknown Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants.
| S-EPMC9934810 | biostudies-literature
Unknown Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants.
| S-EPMC10654096 | biostudies-literature
Unknown OraSure InteliSwab ® Rapid Antigen Test performance with the SARS-CoV-2 Variants of Concern Alpha, Beta, Gamma, Delta, and Omicron.
| S-EPMC8845516 | biostudies-literature
Unknown OraSure InteliSwab™ Rapid Antigen Test Performance with the SARS-CoV-2 Variants of Concern-Alpha, Beta, Gamma, Delta, and Omicron.
| S-EPMC8951130 | biostudies-literature
Unknown Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths.
| S-EPMC8714232 | biostudies-literature
Unknown Diagnostic performance of CerTest and Panbio antigen rapid diagnostic tests to diagnose SARS-CoV-2 infection.
| S-EPMC7897407 | biostudies-literature
Unknown Impaired detection of omicron by SARS-CoV-2 rapid antigen tests.
| S-EPMC8858605 | biostudies-literature
Unknown SARS-CoV-2 antigen-detecting rapid tests for the delta variant.
| S-EPMC8612709 | biostudies-literature
Unknown Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis.
| S-EPMC9324571 | biostudies-literature
Unknown SARS-CoV-2 rapid diagnostic tests for emerging variants.
| S-EPMC8241290 | biostudies-literature