Synthesis, antiplasmodial activity and in silico molecular docking study of pinocembrin and its analogs.

ABSTRACT:

Background

Malaria remains the major health problem responsible for many mortality and morbidity in developing countries. Because of the development of resistance by Plasmodium species, searching effective antimalarial agents becomes increasingly important. Pinocembrin is a flavanone previously isolated as the most active antiplasmodial compound from the leaves of Dodonaea angustifolia. For a better understanding of the antiplasmodial activity, the synthesis of pinocembrin and a great number of analogs was undertaken.

Methods

Chalcones 5a-r were synthesized via Claisen-Schmidt condensation using 2,4-dibenzyloxy-6-hydroxyacetophenone and aromatic aldehydes as substrates under basic conditions. Cyclization of compounds 5a-r to the corresponding dibenzylated pinocembrin analogs

SUBMITTER: Melaku Y 

PROVIDER: S-EPMC9128099 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature