Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep.

ABSTRACT:

Background

Men with prediabetes often exhibit concomitant low-quality sperm production or even infertility, problems which urgently require improved therapeutic options. In this study, we have established a sheep model of diet-induced prediabetes that is associated with spermatogenic defects and have explored the possible underlying metabolic causes.

Results

We compared male sheep fed a normal diet with those in which prediabetes was induced by a rich diet and with a third group in which the rich diet was supplemented by melatonin. Only the rich diet group had symptoms of prediabetes, and in these sheep, we found impaired spermatogenesis characterized by a block in the development of round spermatids and an increased quantity of testicular apoptotic cells. Comparing the gut

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9128135 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature