Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination.

ABSTRACT: Intraperitoneal administration of anticancer nanoparticles is a rational strategy for preventing peritoneal dissemination of colon cancer due to the prolonged retention of nanoparticles in the abdominal cavity. However, instability of nanoparticles in body fluids causes inefficient retention, reducing its anticancer effects. We have previously developed anticancer nanoparticles containing tocopheryl succinate, which showed high in vivo stability and multifunctional anticancer effects. In the present study, we have demonstrated that peritoneal dissemination derived from colon cancer was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. The biodistribution of tocopheryl succinate nanoparticles was evaluated using inductively coupled plasma mass spectroscopy a

SUBMITTER: Hama S 

PROVIDER: S-EPMC9128176 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature