Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer.

ABSTRACT: Obesity increases the risk of colorectal cancer (CRC) by 30%. The obese tumor microenvironment compromises antitumor immunity by eliciting exhausted T cells (Tex). Hypothesizing that Dahuang Fuzi Baijiang decoction (DFB) is a combined classical prescription from the "Synopsis of Prescriptions of the Golden Chamber". We first determined that DFB regresses tumor growth in high-fat diet-induced obese mice by expanding the TIM3^- subset with intermediate expression of programmed cell death-1 (PD-1^int TIM^3- ) and restricting the PD-1^hi TIM3⁺ subset. Transcription factor 1 (TCF1) is highly expressed in the PD-1^int TIM3^- subset but is absent in PD-1^hi TIM3⁺ cells. We next confirmed that progenitor PD

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9128181 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature