Experimental demonstration of tethered gene drive systems for confined population modification or suppression.

ABSTRACT:

Background

Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This could represent a substantial sociopolitical barrier to the testing or deployment of such drives and may generally be undesirable when the objective is only local population control, such as suppression of an invasive species outside of its native range. Tethered drive systems, in which a locally confined gene drive provides the CRISPR nuclease needed for a homing drive, could provide a solution to this problem, offering the power of a homing drive and confinement of the supporting drive.

Results

Here, we demonstrate the engineering of a

SUBMITTER: Metzloff M 

PROVIDER: S-EPMC9128227 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature