A new ferritin SjFer0 affecting the growth and development of Schistosoma japonicum.

ABSTRACT:

Background

Schistosomiasis, an acute and chronic parasitic disease, causes substantial morbidity and mortality in tropical and subtropical regions of the world. Iron is an essential constituent of numerous macromolecules involving in important cellular reactions in virtually all organisms. Trematodes of the genus Schistosoma live in iron-rich blood, feed on red blood cells and store abundant iron in vitelline cells. Ferritins are multi-meric proteins that store iron inside cells. Three ferritin isoforms in Schistosoma japonicum are known, namely SjFer0, SjFer1 and SjFer2; however, their impact on the growth and development of the parasites  is still unknown. In this study we report on and characterize the ferritins in S. japonicum.

Methods

A phylogenetic tree of the SjFer0, 

SUBMITTER: Zeng F 

PROVIDER: S-EPMC9128280 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature