BEXCIS: Bayesian methods for estimating the degree of the skewness of X chromosome inactivation.

ABSTRACT:

Background

X chromosome inactivation (XCI) is an epigenetic phenomenon that one of two X chromosomes in females is transcriptionally silenced during early embryonic development. Skewed XCI has been reported to be associated with some X-linked diseases. There have been several methods measuring the degree of the skewness of XCI. However, these methods may still have several limitations.

Results

We propose a Bayesian method to obtain the point estimate and the credible interval of the degree of XCI skewing by incorporating its prior information of being between 0 and 2. We consider a normal prior and a uniform prior for it (respectively denoted by BN and BU). We also propose a penalized point estimate based on the penalized Fieller's method and derive the corresponding confide

SUBMITTER: Yu WY 

PROVIDER: S-EPMC9128296 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature