Transcriptome and TCR Repertoire Measurements of CXCR3⁺ T Follicular Helper Cells Within HIV-Infected Human Lymph Nodes.

ABSTRACT: Follicular-helper T cells (T_FH) are an essential arm of the adaptive immune system. Although T_FH were first discovered through their ability to contribute to antibody affinity maturation through co-stimulatory interactions with B cells, new light has been shed on their ability to remain a complex and functionally plastic cell type. Due to a lack sample availability, however, many studies have been limited to characterizing T_FH in mice or non-canonical tissue types, such as peripheral blood. Such constraints have resulted in a limited, and sometimes contradictory, understanding of this fundamental cell type. One subset of T_FH receiving attention in chronic infection are CXCR3-expressing T_FH cells (CXCR3⁺T_FH) due to

SUBMITTER: He C 

PROVIDER: S-EPMC9128546 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature