Synergistic Radiosensitization Mediated by Chemodynamic Therapy via a Novel Biodegradable Peroxidases Mimicking Nanohybrid.

ABSTRACT:

Purpose

Reactive oxygen species (ROS) are practically essential in radiotherapy to damage cancer cells; however, they are always inadequate for some malignant entities. Here, we designed a biodegradable mesoporous silica decorated with hemin and glucose oxidase (GOD@Hemin-MSN) to generate a chemodynamic therapy in order to enhance the killing capacity of radiotherapy.

Methods

Mesoporous silica, as an outstanding drug carrier, can deliver hemin and glucose oxidase to the tumor site. With high level of metabolism activity, cancer cells are abundant in glucose, which can be oxidized into H₂O₂ by glucose oxidase (GOD) on site. The generated H₂O₂ is subsequently converted into intracellular ROS, especially hydroxyl radical within the tu

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9128550 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature