Dataset Information

Global Estimates of Capacity for Kidney Transplantation in World Countries and Regions.

ABSTRACT:

Background

Kidney transplantation (KT) is the optimal treatment for kidney failure and is associated with better quality of life and survival relative to dialysis. However, knowledge of the current capacity of countries to deliver KT is limited. This study reports on findings from the 2018 International Society of Nephrology Global Kidney Health Atlas survey, specifically addressing the availability, accessibility, and quality of KT across countries and regions.

Methods

Data were collected from published online sources, and a survey was administered online to key stakeholders. All country-level data were analyzed by International Society of Nephrology region and World Bank income classification.

Results

Data were collected via a survey in 182 countries, of which 155 answered questions pertaining to KT. Of these, 74% stated that KT was available, with a median incidence of 14 per million population (range: 0.04-70) and median prevalence of 255 per million population (range: 3-693). Accessibility of KT varied widely; even within high-income countries, it was disproportionately lower for ethnic minorities. Universal health coverage of all KT treatment costs was available in 31%, and 57% had a KT registry.

Conclusions

There are substantial variations in KT incidence, prevalence, availability, accessibility, and quality worldwide, with the lowest rates evident in low- and lower-middle income countries. Understanding these disparities will inform efforts to increase awareness and the adoption of practices that will ensure high-quality KT care is provided around the world.

SUBMITTER: Mudiayi D

PROVIDER: S-EPMC9128615 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Global Estimates of Capacity for Kidney Transplantation in World Countries and Regions.

Mudiayi Dominic D Shojai Soroush S Okpechi Ikechi I Christie Emily A EA Wen Kevin K Kamaleldin Mostafa M Elsadig Osman Mohamed M Lunney Meaghan M Prasad Bhanu B Osman Mohamed A MA Ye Feng F Khan Maryam M Htay Htay H Caskey Fergus F Jindal Kailash K KK Klarenback Scott S Jha Vivekanand V Rondeau Eric E Turan Kazancioglu Rumeyza R Ossareh Shahrzad S Jager Kitty J KJ Kovesdy Csaba P CP O'Connell Philip J PJ Muller Elmi E Olanrewaju Timothy T Gill John S JS Tonelli Marcello M Harris David C DC Levin Adeera A Johnson David W DW Bello Aminu K AK

Transplantation 20220601 6

<h4>Background</h4>Kidney transplantation (KT) is the optimal treatment for kidney failure and is associated with better quality of life and survival relative to dialysis. However, knowledge of the current capacity of countries to deliver KT is limited. This study reports on findings from the 2018 International Society of Nephrology Global Kidney Health Atlas survey, specifically addressing the availability, accessibility, and quality of KT across countries and regions.<h4>Methods</h4>Data were ...[more]

PMID: 34495014

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Project description:BackgroundQuantifying the proportion of dementia attributable to highly prevalent modifiable risk factors, such as hypertension, is important in informing effective dementia prevention strategies. We aim to quantify the population attributable fraction (PAF) of hypertension for dementia (the proportion of dementia cases that would not occur if hypertension was eliminated) at global, regional, and national levels.MethodsIn this study, we searched international and governmental websites for global, regional, and national data reporting population hypertension (according to 10-year age categories) and dementia prevalence. MEDLINE was searched for studies reporting the risk of dementia from age at hypertension diagnosis from database inception to December 31, 2022. Longitudinal observational studies with >500 participants reporting hazard ratios by age at hypertension diagnosis for risk of future all-cause dementia were eligible for inclusion. Studies excluded had cross-sectional methodology, specific vascular dementia or 'cognitive impairment' outcomes, and no age-specific metrics of association reported. The PAF of hypertension for dementia was calculated globally and for each country and region worldwide.FindingsData from the Global Burden of Disease, United Nations Population Prospectus, NCD Risk Factor Collaboration, UK Biobank, and Atherosclerosis Risk in Communities Study were obtained. 186 countries reported dementia and hypertension prevalence data. The global PAF of hypertension for dementia was 15.8% [95% Credible Interval (CI), 8.8%-22.7%]. Latin America and the Caribbean (18.0% [95% CI, 9.4%-26.6%]), and Europe (17.2% [95% CI, 9.6%-24.7%]) had the highest PAF of hypertension for dementia. Hypertension diagnosed between the ages of 30-44 had the highest age-specific global attributable fraction for dementia (8.4% [95% CI, 3.4%-13.5%]), followed by ages 45-54 (2.92% [ 95% CI, 0.96%-4.88%]), 55-64 (2.59% [95% CI, 1.15%-4.03%]) and 65-74 (1.82% [95% CI, -2.31%-5.96%]).InterpretationThe population attributable risk of hypertension for dementia is 15.8%, suggesting that optimal detection and treatment, particularly at midlife, has the potential to markedly reduce the global burden of dementia.FundingWellcome Trust; Health Research Board of Ireland; Alzheimer's Association.

Dataset Information

Global Estimates of Capacity for Kidney Transplantation in World Countries and Regions.

Background

Methods

Results

Conclusions

Publications

Global Estimates of Capacity for Kidney Transplantation in World Countries and Regions.

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