Transplantation of Extended Criteria Donor Livers Following Continuous Normothermic Machine Perfusion Without Recooling.

ABSTRACT:

Background

Traditional liver transplant strategies with cold preservation usually result in ischemia-reperfusion injury (IRI) to the donor liver. Regular normothermic machine perfusion (NMP) donor livers suffer IRI twice. Here, we aimed to introduce a novel technique called continuous NMP without recooling to avoid a second IRI and its application in livers from extended criteria donors.

Methods

Seven donor livers transplanted following continuous NMP without recooling, 7 donor livers transplanted following standard NMP, and 14 livers under static cold storage (SCS) were included in this study. Perioperative outcomes were recorded and analyzed between groups.

Results

During the NMP without a recooling procedure, all livers cleared lactate quickly to normal levels in a

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9128617 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature