CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons.

ABSTRACT: The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY₁ receptor. These receptors are heterodimers consisting of receptor activity-modifying protein 1 (RAMP1) with either the calcitonin receptor-like receptor (CLR) to form the CGRP receptor or the calcitonin receptor (CTR) to form the AMY₁ receptor. The expression of the CGRP receptor in trigeminal ganglia has been described in several studies; however, there is comparatively limited data available describing AMY₁ receptor expression and in which cellular subtypes it is found. This research aimed to determine the relative distributions of the AMY_1</

SUBMITTER: Rees TA 

PROVIDER: S-EPMC9128745 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature