B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia.

ABSTRACT:

Background

The role of B cell subsets remained to be elucidated in a variety of immune diseases, though which was used as an effective biomarker for anti-inflammatory or antiviral response. This study aimed to evaluate the early changes of B cell subtypes distribution in elderly patients with community acquired pneumonia (CAP), as well as the association between B cell subtypes and prognosis.

Methods

This prospective study included elderly patients with CAP, severe CAP (sCAP) and healthy elderly subjects between April 2016 and March 2018. Flow cytometry was used to detect CD3, CD20, HLA-DR, CD24, CD27, CD38, IgM, and IgD. CD20⁺ B cells were further divided into naïve B cells (Bn), IgM/D⁺ memory B cells (IgM⁺ Bm), switched B cells (SwB), and t

SUBMITTER: Wang CM 

PROVIDER: S-EPMC9128775 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature