A rust fungus effector directly binds plant pre-mRNA splice site to reprogram alternative splicing and suppress host immunity.

ABSTRACT: Alternative splicing (AS) is a crucial post-transcriptional regulatory mechanism in plant resistance. However, whether and how plant pathogens target splicing in their host remains mostly unknown. For example, although infection by Puccinia striiformis f. sp. tritici (Pst), a pathogenic fungus that severely affects the yield of wheat worldwide, has been shown to significantly influence the levels of alternatively spliced transcripts in the host, the mechanisms that govern this process, and its functional consequence have not been examined. Here, we identified Pst_A23 as a new Pst arginine-rich effector that localizes to host nuclear speckles, nuclear regions enriched in splicing factors. We demonstrated that transient expression of Pst_A23 suppresses plant basal defence dependent on the Ps

SUBMITTER: Tang C 

PROVIDER: S-EPMC9129083 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature