A brain network for deep brain stimulation induced cognitive decline in Parkinson's disease.

ABSTRACT: Deep brain stimulation is an effective treatment for Parkinson's disease but can be complicated by side-effects such as cognitive decline. There is often a delay before this side-effect is apparent and the mechanism is unknown, making it difficult to identify patients at risk or select appropriate deep brain stimulation settings. Here, we test whether connectivity between the stimulation site and other brain regions is associated with cognitive decline following deep brain stimulation. First, we studied a unique patient cohort with cognitive decline following subthalamic deep brain stimulation for Parkinson's disease (n = 10) where reprogramming relieved the side-effect without loss of motor benefit. Using resting state functional connectivity data from a large normative cohort (n = 1000),

SUBMITTER: Reich MM 

PROVIDER: S-EPMC9129093 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature