Screening for SARS-CoV-2 in close contacts of individuals with confirmed infection: performance and operational considerations.

ABSTRACT:

Background

Point-of-care and decentralized testing for SARS-CoV-2 is critical to inform public health responses. Performance evaluations in priority use cases such as contact tracing can highlight trade-offs in test selection and testing strategies.

Methods

A prospective diagnostic accuracy study was conducted among close contacts of COVID-19 cases in Brazil. Two anterior nares swabs (ANS), a nasopharyngeal swab (NPS), and saliva were collected at all visits. Vaccination history and symptoms were assessed. Household contacts were followed longitudinally. Three rapid antigen tests and one molecular method were evaluated for usability and performance against reference RT-PCR on NPS.

Results

Fifty index cases and 214 contacts (64 household) were enrolled. Sixty-five cont

SUBMITTER: Zobrist S 

PROVIDER: S-EPMC9129181 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature