Mortality in COVID-19 among women on hormone replacement therapy: a retrospective cohort study.

ABSTRACT:

Background

Limited recent observational data have suggested that there may be a protective effect of oestrogen on the severity of COVID-19 disease. Our aim was to investigate the association between hormone replacement therapy (HRT) or combined oral contraceptive pill (COCP) use and the likelihood of death in women with COVID-19.

Methods

We undertook a retrospective cohort study using routinely collected computerized medical records from the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) primary care database. We identified a cohort of 1,863,478 women over 18 years of age from 465 general practices in England. Mixed-effects logistic regression models were used to quantify the association between HRT or COCP use and all-cause morta

SUBMITTER: Dambha-Miller H 

PROVIDER: S-EPMC9129218 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature