Notch controls the cell cycle to define leader versus follower identities during collective cell migration.

ABSTRACT: Coordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, such as cancer. How cell cycle progression affects migration, and vice versa, remains largely unknown. We address these questions by combining in silico modelling and in vivo experimentation in the zebrafish trunk neural crest (TNC). TNC migrate collectively, forming chains with a leader cell directing the movement of trailing followers. We show that the acquisition of migratory identity is autonomously controlled by Notch signalling in TNC. High Notch activity defines leaders, while low Notch determines followers. Moreover, cell cycle progression is required for TNC migration and is regulated by Notch. Cells with low Notch activity stay longer in G₁ and

SUBMITTER: Alhashem Z 

PROVIDER: S-EPMC9129880 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature