Stem Cell-based Treatment Strategies for Degenerative Diseases of the Retina.

ABSTRACT:

Background

The main cause of progressive vision impairment in retinal degenerative diseases is the dysfunction of photoreceptors and the underlying retinal pigment epithelial cells. The inadequate regenerative capacity of the neural retina and lack of established therapeutic options demand the development of clinical-grade protocols to halt the degenerative process in the eye or replace the damaged cells by using stem cell-derived products. Recently, stem cell-based regenerative therapies have been at the forefront of clinical investigations for retinal dystrophies.

Objective

This article will review different stem cell-based therapies currently employed for retinal degenerative diseases, recent clinical trials, and major challenges in the translation of these therapies from

SUBMITTER: Nair DSR 

PROVIDER: S-EPMC9129886 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature