Investigational Medicinal Products for the Inner Ear: Review of Clinical Trial Characteristics in ClinicalTrials.gov.

ABSTRACT:

Background

The previous 30 years have provided information on the mechanisms of cell death in the inner ear after noise exposure, ototoxic drug injury, and during aging, and clinical trials have emerged for all of these acquired forms of hearing loss. Sudden hearing loss is less well understood, but restoration of hearing after sudden hearing loss is also a long-standing drug target, typically using steroids as an intervention but with other agents of interest as well.

Purpose

The purpose of this review was to describe the state of the science regarding clinical testing of investigational medicinal products for the inner ear with respect to treatment or prevention of acquired hearing loss.

Data collection and analysis

Comprehensive search and summary of clinical trial

SUBMITTER: Le Prell CG 

PROVIDER: S-EPMC9129919 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature