Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities.

ABSTRACT: Preferable antibacterial property and osteogenesis are the permanent pursuit for metallic implants. However, it is difficult to satisfy both the properties. In fact, implants may be contaminated with bacteria during storage and surgery, leading to inflammation. Therefore, the antibacterial property of biomaterial surfaces is required not only in the human environment but also at room temperature. In this study, porous structures loaded with a thermosensitive poly (N-isopropylacrylamide) (PNIPAM) hydrogel on a nitinol (NiTi) substrate were constructed. When the temperature is 25 ​°C, almost all bacteria cannot adhere to the sample surface due to the abundant hydration layer of the PNIPAM hydrogel. Meanwhile, when the temperature is 37 ​°C, the structure of the PNIPAM hydrogel collaps

SUBMITTER: Hao X 

PROVIDER: S-EPMC9130111 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature