Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy.

ABSTRACT:

Purpose

Proviral integration site for Moloney murine leukemia virus (PIMs) are proto-oncogenes encoding serine/threonine kinases that phosphorylate a variety of substrates involved in the regulation of cellular processes. Elevated expression of PIM-1 has been associated with poor prognosis in several types of cancer. There are no studies that have analyzed the response to radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) according to the expression of PIM-1. The aim of our study was to analyze the relationship between the transcriptional expression of PIM-1 and local response to radiotherapy in HNSCC patients.

Methods

We determined the transcriptional expression of PIM-1 in 135 HNSCC patients treated with radiotherapy, including patients treated wit

SUBMITTER: Leon X 

PROVIDER: S-EPMC9130163 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature