Saccharomyces cerevisiae does not undergo a quorum sensing-dependent switch of budding pattern.

ABSTRACT: Saccharomyces cerevisiae can alter its morphology to a filamentous form associated with unipolar budding in response to environmental stressors. Induction of filamentous growth is suggested under nitrogen deficiency in response to alcoholic signalling molecules through quorum sensing. To investigate this further, we analysed the budding pattern of S. cerevisiae cells over time under low nitrogen conditions while concurrently measuring cell density and extracellular metabolite concentration. We found that the proportion of cells displaying unipolar budding increased between local cell densities of 4.8 × 10⁶ and 5.3 × 10⁷ cells/ml. This increase in unipolar budding was not reproduced with cells growing at the critical cell density and in conditioned media. Growth under

SUBMITTER: Winters M 

PROVIDER: S-EPMC9130263 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature