Necroptosis-associated classification combined with tumor microenvironment characteristic analysis of cutaneous melanoma.

ABSTRACT: Necroptosis is a mode of programmed cell death that overcomes apoptotic resistance. The accurate prognosis of cutaneous melanoma is complicated to predict due to tumor heterogeneity. Necroptosis contributes to the regulation of oncogenesis and cancer immunity. We comprehensively investigated different necroptosis patterns by the non-negative matrix factorization (NMF) clustering analysis and explored the relationships among necroptosis patterns, infiltered immune cells, and tumor microenvironment (TME) scores. Two different necroptosis patterns were identified, and the two clusters could predict prognosis and immune landscape. A four-gene signature was successfully constructed and validated its predictive capability of overall survival (OS) in cutaneous melanoma patients. The prognostic va

SUBMITTER: Hu G 

PROVIDER: S-EPMC9130269 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature