MTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients.

ABSTRACT:

Background

Aberrant activation of the mammalian Target of Rapamycin (mTOR) pathway has been linked to obesity and endocrine therapy resistance, factors that may contribute to Black-White disparities in breast cancer outcomes. We evaluated associations of race and clinicopathological characteristics with mRNA expression of key mTOR pathway genes in breast tumors.

Methods

Surgical tumor tissue blocks were collected from 367 newly diagnosed breast cancer patients (190 Black and 177 White). Gene expression of AKT1, EIF4EBP1, MTOR, RPS6KB2, and TSC1 were quantified by NanoString nCounter. Differential gene expression was assessed using linear regression on log2-transformed values. Gene expression and DNA methylation data from TCGA were used for validation and investigation of rac

SUBMITTER: Ilozumba MN 

PROVIDER: S-EPMC9130392 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature