Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis.

ABSTRACT: Immune activation accompanies the development of proteinopathy in the brains of Alzheimer's dementia patients. Evolving from the long-held viewpoint that immune activation triggers the pathological trajectory in Alzheimer's disease, there is accumulating evidence now that microglial activation is neither pro-amyloidogenic nor just a simple reactive process to the proteinopathy. Preclinical studies highlight an interesting aspect of immunity, i.e., spurring immune system activity may be beneficial under certain circumstances. Indeed, a dynamic evolving relationship between different activation states of the immune system and its neuronal neighbors is thought to regulate overall brain organ health in both healthy aging and progression of Alzheimer's dementia. A new premise evolving from geno

SUBMITTER: McFarland KN 

PROVIDER: S-EPMC9130399 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature