Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel.

ABSTRACT:

Background

Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney's ability to filter waste and excess water. Hydrogels are promising material for medical applications owing to their excellent adaptability and filling ability. Herein, we proposed a hyaluronic acid/gelatin (CHO-HA/Gel-NH₂) bioactive hydrogel as a cell carrier for therapeutic kidney regeneration in IgAN.

Methods

CHO-HA/Gel-NH₂ hydrogel was fabricated by Schiff-base reaction without any additional crosslinking agents. The hydrogel concentrations and ratios were evaluated to enhance adequate mechanical properties and biocompatibility for further in vivo study. High serum IgA d

SUBMITTER: Khunmanee S 

PROVIDER: S-EPMC9130434 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature