Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155.

ABSTRACT:

Background

Understanding mechanisms of pathologic neuroinflammation is essential for improving outcomes after central nervous system infections. Brain tissue-resident memory T cells (bT_RM) are recruited during central nervous system infection and promote pathogen control as well as noxious inflammation. Our prior studies in young mice showed optimal recruitment of CD8⁺ bT_RM during neuroinvasive Listeria monocytogenes (Lm) infection required miR-155, and was significantly inhibited by anti-miR-155 oligonucleotides. Since Lm is an important pathogen in the elderly, we hypothesized anti-miR-155 would also inhibit accumulation of CD8⁺ bT_RM in aged mice infected with Lm.

Methods

Young (2 mo) and aged (> 18 mo) male C57BL/6 mi

SUBMITTER: Cassidy BR 

PROVIDER: S-EPMC9130456 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature