An Emerging Frontier in Intercellular Communication: Extracellular Vesicles in Regeneration.

ABSTRACT: Regeneration requires cellular proliferation, differentiation, and other processes that are regulated by secreted cues originating from cells in the local environment. Recent studies suggest that signaling by extracellular vesicles (EVs), another mode of paracrine communication, may also play a significant role in coordinating cellular behaviors during regeneration. EVs are nanoparticles composed of a lipid bilayer enclosing proteins, nucleic acids, lipids, and other metabolites, and are secreted by most cell types. Upon EV uptake by target cells, EV cargo can influence diverse cellular behaviors during regeneration, including cell survival, immune responses, extracellular matrix remodeling, proliferation, migration, and differentiation. In this review, we briefly introduce the history of

SUBMITTER: Avalos PN 

PROVIDER: S-EPMC9130466 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature