The relationship between disease activity and UDCA response criteria in primary biliary cholangitis: A cohort study.

ABSTRACT:

Background

Uncertainty exists about how best to identify primary biliary cholangitis (PBC) patients who would benefit from second-line therapy. Existing, purely clinical, ursodeoxycholic acid (UDCA) response criteria accept degrees of liver biochemistry abnormality in responding patients, emerging data, however, suggest that any degree of ongoing abnormality may, in fact, be associated with an increased risk of adverse outcomes. This cohort study explores the link between response status, the biology of high-risk disease and its implications for clinical practice.

Methods

Proteomics, exploring 19 markers previously identified as remaining elevated in PBC following UDCA therapy, were performed on 400 serum samples, from participants previously recruited to the UK-PBC Nested C

SUBMITTER: Jones DEJ 

PROVIDER: S-EPMC9130524 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature