Novel interaction of properdin and coagulation factor XI: Crosstalk between complement and coagulation.

ABSTRACT:

Background

Evidence of crosstalk between the complement and coagulation cascades exists, and dysregulation of either pathway can lead to serious thromboinflammatory events. Both the intrinsic pathway of coagulation and the alternative pathway of complement interact with anionic surfaces, such as glycosaminoglycans. Hitherto, there is no evidence for a direct interaction of properdin (factor P [FP]), the only known positive regulator of complement, with coagulation factor XI (FXI) or activated FXI (FXIa).

Objectives

The aim was to investigate crosstalk between FP and the intrinsic pathway and the potential downstream consequences.

Methods

Chromogenic assays were established to characterize autoactivation of FXI in the presence of dextran sulfate (DXS), enzyme kinetics

SUBMITTER: Heal SL 

PROVIDER: S-EPMC9130567 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature