Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection.

ABSTRACT: Cytokine storms and extra-activated cytokine signaling pathways can lead to severe tissue damage and patient death. Activation of inflammatory signaling pathways during Cytokine storms are an important factor in the development of acute respiratory syndrome (SARS-CoV-2), which is the major health problem today, causing systemic and local inflammation. Cytokine storms attract many inflammatory cells that attack the lungs and other organs and cause tissue damage. Angiotensin-converting enzyme 2 (ACE2) are expressed in a different type of tissues. inhibition of ACE2 activity impairs renin-angiotensin (RAS) function, which is related to the severity of symptoms and mortality rate in COVID-19 patients. Different signaling cascades are activated, affecting various organs during SARS-CoV-2 infect

SUBMITTER: Rasmi Y 

PROVIDER: S-EPMC9130726 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature