Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD.

ABSTRACT:

Background

Improved understanding of the pathways associated with airway pathophysiologic features in COPD will identify new predictive biomarkers and novel therapeutic targets.

Research question

Which physiologic pathways are altered in the airways of patients with COPD and will predict exacerbations?

Study design and methods

We applied a mass spectrometric panel of metabolomic biomarkers related to mucus hydration and inflammation to sputa from the multicenter Subpopulations and Intermediate Outcome Measures in COPD Study. Biomarkers elevated in sputa from patients with COPD were evaluated for relationships to measures of COPD disease severity and their ability to predict future exacerbations.

Results

Sputum supernatants from 980 patients were analyzed: 77 he

SUBMITTER: Esther CR 

PROVIDER: S-EPMC9131049 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature