The Right Heart Network and Risk Stratification in Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Prognosis in pulmonary arterial hypertension (PAH) is closely related to indexes of right ventricular function. A better understanding of their relationship may provide important implications for risk stratification in PAH.

Research question

Can clinical network graphs inform risk stratification in PAH?

Study design and methods

The study cohort consisted of 231 patients with PAH followed up for a median of 7.1 years. An undirected, correlation network was used to visualize the relationship between clinical features in PAH. This network was enriched for right heart parameters and included N-terminal pro-hormone B-type natriuretic peptide (NT-proBNP), comprehensive echocardiographic parameters, and hemodynamics, as well as 6-min walk distance (6MWD), vital si

SUBMITTER: Haddad F 

PROVIDER: S-EPMC9131051 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature