Mathematical modelling of the most effective goal of cholesterol-lowering treatment in primary prevention.

ABSTRACT:

Objective

To compare quantitatively different recommended goals for cholesterol-lowering treatment in the primary prevention of atherosclerotic cardiovascular disease (ASCVD).

Design

Outcomes at pretreatment low-density lipoprotein (LDL) cholesterol concentrations from 2 to 5 mmol/L and 10-year ASCVD risk from 5% to 30% were modelled, using the decrease in risk ratio per mmol/L reduction in LDL cholesterol derived from randomised controlled trials (RCTs) of cholesterol-lowering medication.

Data source

Summary statistics from 26 RCTs comparing treatment versus placebo or less versus more effective treatment and 12 RCTs in which statin was compared with a higher dose of the same statin or with a similar statin dose to which an adjunctive cholesterol-lowering drug was ad

SUBMITTER: Soran H 

PROVIDER: S-EPMC9131112 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature