Triple-serotype chimeric oncolytic adenovirus exerts multiple synergistic mechanisms against solid tumors.

ABSTRACT:

Background

Oncolytic virotherapy has become an important branch of cancer immunotherapy. This study investigated the efficacy of an oncolytic adenovirus (OAV), OncoViron, with synergistic mechanisms in the treatment of multiple solid tumors.

Methods

An OAV, OncoViron, was constructed and investigated by cytological experiments and implanted tumor models of multiple solid tumor cell lines to certify its anticancer efficacy, the synergistic effects of viral oncolysis and transgene anticancer activity of OncoViron, as well as oncolytic virotherapy combined with immunotherapy, were also verified.

Results

The selective replication of OncoViron mediated high expression of anticancer factors, specifically targeted a variety of solid tumors and significantly inhibited cancer

SUBMITTER: Su Y 

PROVIDER: S-EPMC9131115 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature