Opportunities for Molecular Imaging in Multiple Sclerosis Management: Linking Probe to Treatment.

ABSTRACT: Imaging has been a critical component of multiple sclerosis (MS) management for nearly 40 years. The visual information derived from structural MRI, that is, signs of blood-brain barrier disruption, inflammation and demyelination, and brain and spinal cord atrophy, are the primary metrics used to evaluate therapeutic efficacy in MS. The development of targeted imaging probes has expanded our ability to evaluate and monitor MS and its therapies at the molecular level. Most molecular imaging probes evaluated for MS applications are small molecules initially developed for PET, nearly half of which are derived from U.S. Food and Drug Administration-approved drugs and those currently undergoing clinical trials. Superparamagnetic and fluorinated particles have been used for tracking circulating

SUBMITTER: Thomas AM 

PROVIDER: S-EPMC9131169 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature